Stem cells restore motor function in Parkinson's disease patients
Very exciting news for advanced Parkinson's disease patients. With all the caveats associated with a 12-patient open-label study, the...
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Songsong CaO
Aug 31, 20231 min read
Unintended consequences of Inflation Reduction Act
"The threat of the Inflation Reduction Act is so severe that Merck has fielded questions about whether it would choose to delay the...
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Songsong CaO
Aug 31, 20231 min read
PROTAC another weapon to attack neurodegeneration
Pretty exciting news for the neurodegeneration field for a PROTAC leader like Arvinas to jump in, providing another modality tool. For a...
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Songsong CaO
Aug 31, 20231 min read
Smoking cessation drugs for long-term cardiovascular benefits just like Wegovy?
Am I totally crazy to think this way? Wegovy cut the risk of major cardiovascular adverse events by 20% after 5 years and it's annual...
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Songsong CaO
Aug 31, 20231 min read
IPF remains a grave yard for clinical trials
The Ph2 failure of Galecto's GB0139 is a salient reminder that IPF remains a grave yard for clinical trials while patients continue to...
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Songsong CaO
Aug 8, 20231 min read
Voyager adds anti-amyloid gene therapy to pipeline
Interesting approach to trying to avoid ARIA issues faced by #leqembi and #donanemab, at least hypothetically. I'm curious about a few...
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Songsong CaO
Aug 8, 20231 min read
Donanemab Ph3 results are out
Lilly's donanemab Ph3 TRAILBLAZER ALZ-2 full results are out. A few really interesting observations from my perspective: 1. By 76 weeks,...
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Songsong CaO
Aug 8, 20231 min read
FDA-approved Alzheimer's drug is just the beginning
Safety issues and high price of the current anti-amyloid drugs definitely prevent them from being used before Alzheimer's symptoms...
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Songsong CaO
Aug 8, 20231 min read
Quanterix launches prescription blood test for Alzheimer's disease
This kind of blood-based test will be a big deal for accelerating the adoption of newly approved Alzheimer's drugs. This reminds me of an...
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Songsong CaO
Aug 8, 20232 min read
FDA grants accelerated approval for Alzheimer's disease treatment
Geat news for Alzheimer's disease patients and a satisfying outcome for Eisai and Biogen, which have been very resilient in the fight...
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Songsong CaO
Aug 8, 20231 min read
JnJ's Protagonist-licensed psoriasis drug falls short in Ph2 trial
Disappointing results for psoriasis patients waiting for a pill that's as effective as second generation biologics like anti-IL-17 and...
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Songsong CaO
Aug 8, 20231 min read
Unraveling complexities of AI in drug discovery
A very candid article about the limitations of AI in drug discovery. If all the #drugdiscovery companies can be more candid about what...
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Songsong CaO
Aug 8, 20231 min read
Lilly buys Dice Therapeutics
#immunology is red-hot now with another major acquistion following Merck's Prometheus acquisition. In the case of Dice, the thesis is...
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Songsong CaO
Aug 8, 20231 min read
Anti-amyloid drug data readout drives up APOE testing
Interesting finding by Truveta. A 125% increase of APOE4 status testing rate during 09/22-01/23 period vs. 09/21-01/22, possibly due to...
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Songsong CaO
Aug 8, 20231 min read
3 Waves of AI in TechBio
AI is a tool you can use to accelerate drug discovery and development in some aspects. Don't expect to blow potential pharma partners and...
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Songsong CaO
Aug 8, 20231 min read
BIO Panel "Perspectives on Target Selection: How Companies Approach a Critical Decision"
A great session on target selection at BIO "Perspectives on Target Selection: How Companies Approach a Critical Decision", including...
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Songsong CaO
Aug 8, 20231 min read
BIO panel on how to turn how to turn platform technologies into life-changing therapeutics
It was wonderful to listen to an all-female panel on how to turn platform technologies into life-changing therapeutics. My key takeaways...
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Songsong CaO
Aug 8, 20231 min read
AZ cuts late-stage IL-23 drug due to trial delays, competitive landscape
Smart move, but could've been done earlier. It highlights two things: 1. There's always a tendency to keep a program alive for too long,...
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Songsong CaO
Aug 8, 20232 min read
3 Lessons I learned from starting my own business
#Target2Drug bioAdvisory has been in business for 4 months and I've won 4 clients. I'm extremely proud of the fact that 3 out of my 4...
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Songsong CaO
Aug 8, 20231 min read
EQRx lays off more than half of employees
Did EQRx underestimate all the hurdles to disrupt the US drug pricing from the get-go? Or its ambition was really crushed by unexpected...
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